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Infect Immun. 1970 May; 1(5): 459-463
Copyright © 1970 American Society for Microbiology. All Rights Reserved.

research-article

Infection of Cultured Mouse Macrophages with Shigella flexneri

^a Department of Epidemiology and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15213

ABSTRACT

Virulent, avirulent, and attenuated hybrid strains of Shigella flexneri 2a are equally susceptible to phagocytosis by cultured mouse peritoneal macrophages. The virulent strain is highly lethal for the macrophages, whereas the avirulent is not and is killed. The attenuated hybrid strain is intermediate in its lethality. Comparable results were obtained by using virulent and avirulent S. flexneri 1b, 3, and 5. Destruction of macrophages occurs shortly after infection, suggesting virulent strains may possess a toxic component. The relationship of the ability to kill macrophages with multiplication of virulent shigellae in mucosal tissue is discussed.

¹ Present address: Department of Biochemistry and Nutrition, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pa. 15213.

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