This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Guze, L. B. Articles by Kalmanson, G. M. Search for Related Content PubMed PubMed Citation Articles by Guze, L. B. Articles by Kalmanson, G. M.

 Previous Article  |  Next Article 

Infect Immun. 1970 June; 1(6): 532-537
Copyright © 1970 American Society for Microbiology. All Rights Reserved.

research-article

Pyelonephritis XI. Effect of Growth Phase of Streptococcus faecalis on Serum Susceptibility and Virulence

Veterans Administration Center, Los Angeles, California 90073
School of Medicine, University of California, Los Angeles, California 90024

ABSTRACT

Rapidly growing Streptococcus faecalis was found to be markedly susceptible to the bactericidal activity of normal rat and rabbit sera, whereas stationary-phase organisms were resistant. In contrast, human serum killed neither phase organism. Further, human serum was found to interfere with killing by rabbit serum. The serosusceptible, rapidly growing organisms were less virulent than the seroresistant, stationary-phase organisms. This was tested by production of pyelonephritis in the rat after intravenous inoculation of the organism. Renal bacterial content over a period of 4 weeks was significantly less in those animals which had received rapidly growing organisms.