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Infect Immun. 1970 June; 1(6): 566-573
Copyright © 1970 American Society for Microbiology. All Rights Reserved.

research-article

Protective Effect of a Synthetic Polynucleotide Complex (Poly I: C) on Ocular Lesions Produced by Trachoma Agent in Rabbits

¹ Francis I. Proctor Foundation and George Williams Hooper Foundation, University of California Medical Center, San Francisco, California 94122

ABSTRACT

Live trachoma agent (TE55) injected into the anterior chamber of the rabbit eye produced the following agent-specific ocular lesions: corneal opacity, corneal neovascularization, and iritis. Three intravenous injections of 1 mg of a potent interferon (IF) inducer, polyriboinosinic acid-polyribocytidylic acid complex (poly I:C), markedly suppressed the ocular lesions produced by the trachoma agent but failed to inhibit the growth of the agent in the ocular tissues. Furthermore, a single intravenous injection of 1 mg of polyriboinosinic acid or of polyribocytidylic acid was also protective, although each failed to induce any detectable circulating IF. These results indicate that a factor or factors other than IF may play a role in the suppression of the ocular lesions produced by trachoma agent in poly I:C-injected rabbits.