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Infect Immun. 1974 July; 10(1): 197-203
Copyright © 1974 American Society for Microbiology. All Rights Reserved.

Diminished Virulence of Glucan Synthesis-Defective Mutants of Streptococcus mutans

J. M. Tanzer, M. L. Freedman, R. J. Fitzgerald and R. H. Larson

University of Connecticut Health Center, Farmington, Connecticut 06032
Veterans Administration Hospital, Miami, Florida 33125
National Institute of Dental Research, Bethesda, Maryland 20014

ABSTRACT

The virulence of cell surface-associated, glucan synthesis-defective mutants of Streptococcus mutans strain 6715-13 was studied. Representatives from three groups of such mutants were tested for their pathogenicity in conventionalized, specific pathogen-free rats and gnotobiotic rats. The mutants differ from the wild-type strain in that each failed to form plaque on the smooth surfaces of the teeth and to cause smooth surface caries. Although the ability to form cell surface-associated glucans was not a strict requirement for the expression of virulence in the sulci of the teeth, it augmented virulence at such sites. However, the ability to form cell surface-associated glucans and to adhere to the teeth was clearly not the sole determinant of virulence.

Infect Immun. 1974 July; 10(1): 197-203
Copyright © 1974 American Society for Microbiology. All Rights Reserved.



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