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Infect Immun. 1974 November; 10(5): 1018-1022
Copyright © 1974 American Society for Microbiology. All Rights Reserved.

Cell-Mediated Immune Responses of Preleukemic AKR Mice

School of Life Sciences, University of Nebraska, Lincoln, Nebraska 68508

ABSTRACT

Splenic lymphocytes from preleukemic AKR mice are capable of participating in various cell-mediated immune responses. Spleen cells from AKR mice aged 1 to 10 months produced a significant graft-versus-host reaction when injected into 8-day-old AKR x C57Bl/6 F₁ hybrids. Splenic lymphocytes from similarly aged mice were also capable of responding to allogenic stimulation in a mixed lymphocyte reaction. AKR mice aged 1 to 10 months developed a contact sensitivity response to picryl chloride. It was concluded that mice of this high-leukemic strain have a competent cell-mediated immune system and there is no depression of immunity during the preleukemic period.