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Infect Immun. 1974 November; 10(5): 1029-1033
Copyright © 1974 American Society for Microbiology. All Rights Reserved.

Enhancement of Primary Antigen-Specific Resistance in Infant Mice with Divinyl Ether-Maleic Anhydride

¹ Plum Island Animal Disease Center, Northeastern Region Agricultural Research Service, Greenport, New York 11944

ABSTRACT

The early response of infant mice to foot-and-mouth disease viral antigens, measured by greater resistance and increased serum-neutralizing antibody, was enhanced by divinyl ether-maleic anhydride (DVE/MA). Preparations of known antigen concentration were used to study various parameters influencing this enhancement. Resistance and antibody levels were increased when DVE/MA was administered with aqueous or oil-emulsified antigens, whether given separately or mixed with the antigens, but was dependent on the dose and route of the DVE/MA and antigen. Enhanced resistance developed rapidly, was antigen-specific, and may have been related to the level of neutralizing antibody.