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Infect Immun. 1974 November; 10(5): 1057-1061
Copyright © 1974 American Society for Microbiology. All Rights Reserved.

Differential Production of Interferon and Refractoriness Inducing Principle in L Cells

¹ Department of Medical Viral Oncology, Roswell Park, Memorial Institute, and the Graduate Faculty in Microbiology, State University of New York at Buffalo, Buffalo, New York 14203

ABSTRACT

The extracellular, acid-soluble cell products (EASCP) from Newcastle disease virus-infected L₉₂₉ cells contain both interferon, defined as antiviral activity, and refractoriness inducing principle, defined as an activity that inhibits interferon production. L cells pretreated with EASCP and then infected with Newcastle disease virus give rise to EASCP with decreased amounts of interferon but an increased ratio of refractoriness inducing principle activity to interferon activity in a dose related manner. The antiviral activity of an EASCP preparation is not dependent upon its refractoriness inducing principle level, but is entirely dependent on its interferon content. Our results provide additional evidence that interferon and refractoriness inducing principle are different biological entities and not polymorphic functions of the interferon molecule.