This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kantzler, G. B. Articles by Waldman, R. H. Search for Related Content PubMed PubMed Citation Articles by Kantzler, G. B. Articles by Waldman, R. H.

 Previous Article  |  Next Article 

Infect Immun. 1974 November; 10(5): 996-1002
Copyright © 1974 American Society for Microbiology. All Rights Reserved.

Immunosuppression During Influenza Virus Infection

Departments of Medicine and Immunology and Medical Microbiology, College of Medicine, University of Florida, Gainesville, Florida 32610
Veterans Administration Hospital, Gainesville, Florida 32602

ABSTRACT

The effects of a live attenuated influenza vaccine and subsequent challenge with virulent influenza virus on the delayed hypersensitivity skin test, and the in vitro response of lymphocytes were evaluated. Volunteers were skin tested before and after administration of vaccine or placebo and challenge with PPD (a purified protein derivative of Mycobacterium tuberculosis), candida, mumps, and trichophytin, and their lymphocytes were tested for [³H]thymidine uptake in response to phytohemagglutin. Of eight volunteers who showed evidence of viral replication after administration of the attenuated vaccine, four had a significant diminution in their skin test response, whereas 8 of 13 volunteers infected with virulent influenza virus showed a diminution. Of the 21 volunteers who were infected with either attenuated or virulent influenza virus, 12 showed suppression of their phytohemagglutin response. None of the volunteers who were given placebo vaccine, or who showed no evidence for viral replication after immunization or challenge, had a suppression of their skin test or phytohemagglutin responses. Although most of the infected volunteers demonstrated suppression of their T-cell function, there was no evidence of a similar suppression of B-cell function.

This article has been cited by other articles:

• Carrat, F., Vergu, E., Ferguson, N. M., Lemaitre, M., Cauchemez, S., Leach, S., Valleron, A.-J. (2008). Time Lines of Infection and Disease in Human Influenza: A Review of Volunteer Challenge Studies. Am J Epidemiol 167: 775-785 [Abstract] [Full Text]