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Infect Immun. 1974 December; 10(6): 1202-1206
Copyright © 1974 American Society for Microbiology. All Rights Reserved.

Antiviral Activity of an Ether-Extracted Nonviable Preparation of Brucella abortus

¹ Department of Microbiology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261

ABSTRACT

Extraction of living Brucella abortus (strain 456) with aqueous ether yielded a nonviable, insoluble residue (Bru-Pel). When injected into mice, Bru-Pel was an effective, nontoxic interferon stimulus. Mice pretreated with Bru-Pel were protected against challenge with otherwise lethal doses of Semliki Forest virus. Significant protection was afforded when Bru-Pel was given as many as 7 days before virus challenge. Evidence is presented dealing with the complex nature of Bru-Pel and with the possibility that the antiviral activity of Bru-Pel may be associated not only with the production of interferon, but with a general increase in the level of nonspecific resistance in animals.