This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Stevens, J G Articles by Jordan, M C Search for Related Content PubMed PubMed Citation Articles by Stevens, J G Articles by Jordan, M C

Reactivation of latent Herpes simplex virus after pneumococcal pneumonia in mice.

ABSTRACT

In attempts to reactivate latent herpes simplex virus, we instilled Diplococcus pneumoniae intratracheally into mice harboring latent infections in sacrosciatic spinal ganglia. All mice developed a severe pneumonia within 24 h and were given penicillin therapy. Representative mice that survived the penumonia were sacrificed at daily intervals, and appropriate tissues were examined for evidence of viral reactivation. Herpes simplex virus was reactivated in the ganglia and appeared to travel both proximally and distally in associated nerve trunks. Clinically apparent disease due to the virus was not detected in any mice.

This article has been cited by other articles:

• Campbell, K. E., Brundage, J. F. (2002). Effects of Climate, Latitude, and Season on the Incidence of Bell's Palsy in the US Armed Forces, October 1997 to September 1999. Am J Epidemiol 156: 32-39 [Abstract] [Full Text]  
• Cantin, E., Tanamachi, B., Openshaw, H. (1999). Role for Gamma Interferon in Control of Herpes Simplex Virus Type 1 Reactivation. J. Virol. 73: 3418-3423 [Abstract] [Full Text]  
• Sekizawa, T, Openshaw, H, Wohlenberg, C, Notkins, A. (1980). Latency of herpes simplex virus in absence of neutralizing antibody: model for reactivation. Science 210: 1026-1028 [Abstract]