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Effect of Trace Metals on Phagocytosis by Alveolar Macrophages

¹ Experimental Biology Laboratory, Pathobiology Research Branch, Environmental Protection Agency, Research Triangle Park, North Carolina 27711

ABSTRACT

Experiments were performed to measure the effect of trace metals on a vital function of the alveolar macrophage (AM), phagocytosis. Since certain trace metals were found to reduce the viability of AMs, a technique was developed to permit examination of live cells only for phagocytosis. Evidence is presented that Ni²⁺ selectively altered the phagocytic activity of AMs at concentrations lower than those which caused cell death. It is further shown that a level of VO₃^– that caused extensive lysis and death did not reduce phagocytosis in surviving cells. The effects of Cd²⁺, Cr³⁺, and Mn²⁺ on AMs were also examined.

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• Steinkamp, J., Wilson, J., Saunders, G., Stewart, C. (1982). Phagocytosis: flow cytometric quantitation with fluorescent microspheres. Science 215: 64-66 [Abstract]