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Infect Immun. 1975 September; 12(3): 571-575

Klebsiella pneumoniae and Staphylococcus aureus infection in mice: difference in uremia and ammoniagenesis.

R I Walker and W Chesbro

ABSTRACT

Lethal infections by Staphylococcus aureus and Klebsiella pneumoniae were compared for kidney-related effects in mice. K. pneumoniae caused uremia and an increase in blood ammonia that could reach 2.5 times normal. These events did not occur in mice inoculated with S. aureus. Use of germfree animals indicated that most of the increase in ammonia arose from the gut, presumably due to greater availability of urea and ureolysis. Injected ornithine restored blood ammonia to nearly normal levels and extended survival.

Infect Immun. 1975 September; 12(3): 571-575






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Copyright © 1975 by the American Society for Microbiology. All rights reserved.