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Infect Immun. 1975 November; 12(5): 943-946

Effect of the antitumor antibiotic chromomycin A3 on the humoral immune response in rats.

R Nayak, K S Prasad and M Sirsi

ABSTRACT

Chromomycin A3 (250 mug/kg) suppressed the humoral immune response in rats against sheep erythrocytes when administered 48 h or later after antigenic stimulus. The antibiotic at this dose enhanced immunity when given along with or before antigen administration. The natural heterohemagglutinin levels in rabbits and guinea pigs were not affected by the antibiotic (10 mug/kg per day x 7).

Infect Immun. 1975 November; 12(5): 943-946






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Copyright © 1975 by the American Society for Microbiology. All rights reserved.