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Infect Immun. 1976 March; 13(3): 844-854

Genetically determined resistance to infection by hepatotropic influenza A virus in mice: effect of immunosuppression.

ABSTRACT

Mice carrying the gene Mx were resistant to the lethal action of a hepatotropic line of avian influenza A virus. In resistant animals, foci of liver necrosis were self-limiting, and maximal virus titers reached were much below those in susceptible animals. Resistance could not be abrogated by immunosuppressive treatment with cyclophosphamide, methotrexate, or procarbazine, although such treatment prevented cellular infiltration at sites of virus replication and appeared to delay virus clearance. Silica and thorium dioxide, thought to inhibit macrophage function, likewise failed to abolish resistance. Regenerating liver tissue did not support more extensive virus replication than did intact adult liver.

This article has been cited by other articles:

• Engelhardt, O. G., Sirma, H., Pandolfi, P.-P., Haller, O. (2004). Mx1 GTPase accumulates in distinct nuclear domains and inhibits influenza A virus in cells that lack promyelocytic leukaemia protein nuclear bodies. J. Gen. Virol. 85: 2315-2326 [Abstract] [Full Text]