This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Rogers, T Articles by Balish, E Search for Related Content PubMed PubMed Citation Articles by Rogers, T Articles by Balish, E

 Previous Article  |  Next Article 

Infect Immun. 1976 July; 14(1): 33-38

Experimental Candida albicans infection in conventional mice and germfree rats.

ABSTRACT

Swiss-Webster white mice were intravenously infected with various doses of Candida albicans, and the viable units in their spleens, livers, lungs, and kidneys were determined at various intervals after challenge. The results showed that C. albicans multiplied to a greater extent in the kidneys of mice than in their spleens, lungs, or livers. The infection in mice was chronic; increasing numbers of C. albicans were observed in their kidneys until about 17 to 24 days postchallenge. Clearance of C. albicans from infected kidneys was not symmetrical, since the number of viable C. albicans in one kidney did not coincide with the viable counts observed in the opposite kidney of that same animal. Male and female mice did not differ in their overall susceptibility (50% lethal dose test) or in the number of viable C. albicans in the kidneys at various time intervals after infection. C. albicans also multiplied in the kidneys of germfree rats; however, the peak of the C. albicans infection in their kidneys occurred earlier than in those of conventional mice.

This article has been cited by other articles:

• Blankenship, J. R., Heitman, J. (2005). Calcineurin Is Required for Candida albicans To Survive Calcium Stress in Serum. Infect. Immun. 73: 5767-5774 [Abstract] [Full Text]