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Infect Immun. 1976 July; 14(1): 88-94

Induction of interferon in ovine and human lymphocyte cultures by mycoplasmas.

B C Cole, J C Overall Jr, P S Lombardi and L A Glasgow

ABSTRACT

Mycoplasma pneumoniae, Acholeplasma laidlawii, M. arthritidis, and M. pulmonis were shown to induce interferon in the lymphocyte fraction of ovine peripheral blood leukocytes, but not in the polymorphonuclear leukocyte fraction. Human peripheral blood lymphocytes produced significant levels of interferon in response to infection with M. pneumoniae and M. synoviae. The antiviral substance induced by the mycoplasmas in human lymphocytes was characterized as interferon by the usual criteria.

Infect Immun. 1976 July; 14(1): 88-94




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