This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Good, A H Articles by Miller, K L Search for Related Content PubMed PubMed Citation Articles by Good, A H Articles by Miller, K L

 Previous Article  |  Next Article 

Infect Immun. 1976 August; 14(2): 449-456

Depression of the immune response to sheep erythrocytes in mice infected with Taenia crassiceps larvae.

ABSTRACT

Intraperitoneal infection of mice with larvae of the cestode parasite Taenia crassiceps results in depression of both primary and secondary antibody responses to sheep erythrocytes in vivo. The depression is not associated with a shift in kinetics of the response. Both immunoglobulin M (IgM) and IgG responses are depressed, but IgG is depressed more than IgM in the secondary response. Secondary in vitro sheep erythrocyte responses are consistently depressed in both spleen and mesenteric lymph node cell preparations from infected mice, whereas primary in vitro sheep erythrocyte responses are consistently depressed in mesenteric lymph node cell preparations but not always in spleen cell preparations. These results are consistent with antigenic competition. The cell type or types involved in mediation of the immunological defect in the infected animals remain to be identified.