This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Rinaldo, C R Articles by Scott, F W Search for Related Content PubMed PubMed Citation Articles by Rinaldo, C R, Jr Articles by Scott, F W

 Previous Article  |  Next Article 

Infect Immun. 1976 September; 14(3): 660-666

Fetal and adult bovine interferon production during bovine viral diarrhea virus infection.

ABSTRACT

Levels of interferon in adult bovine serum and in fetal bovine serum and tissues were examined during the course of transplacental bovine viral diarrhea virus infection. The cows produced circulating interferon between 2 and 9 days after viral inoculation, with mean peak levels in the serum on day 4. Interferon could be routinely detected in fetal tissues (e.g., thymus, spleen, and kidney) between days 4 and 21 after viral inoculation of the cows at 149 to 150 days of gestation (mid-second trimester) and in fetal serum from day 13 through day 21. Interferon was also detectable in the serum and tissues of fetuses from dams infected at day 95 of gestation (the beginning of the second trimester). In general, no differences were found between the ability of the adult and fetus to produce interferon. Fetal lamb kidney cells were more sensitive to the antiviral effects of bovine interferon than were fetal bovine kidney cells. The antiviral substance from the fetal and adult animals was characterized as interferon by standard criteria.

This article has been cited by other articles:

• Muller-Doblies, D., Arquint, A., Schaller, P., Heegaard, P. M. H., Hilbe, M., Albini, S., Abril, C., Tobler, K., Ehrensperger, F., Peterhans, E., Ackermann, M., Metzler, A. (2004). Innate Immune Responses of Calves during Transient Infection with a Noncytopathic Strain of Bovine Viral Diarrhea Virus. CVI 11: 302-312 [Abstract] [Full Text]  
• Belland, R. J., Scidmore, M. A., Crane, D. D., Hogan, D. M., Whitmire, W., McClarty, G., Caldwell, H. D. (2001). Chlamydia trachomatis cytotoxicity associated with complete and partial cytotoxin genes. Proc. Natl. Acad. Sci. USA 10.1073/pnas.241377698v1 [Abstract] [Full Text]  
• Xiang, J., Wunschmann, S., Diekema, D. J., Klinzman, D., Patrick, K. D., George, S. L., Stapleton, J. T. (2001). Effect of Coinfection with GB Virus C on Survival among Patients with HIV Infection. NEJM 345: 707-714 [Abstract] [Full Text]  
• Swasdipan, S., Bielefeldt-Ohmann, H., Phillips, N., Kirkland, P. D., McGowan, M. R. (2001). Rapid Transplacental Infection with Bovine Pestivirus Following Intranasal Inoculation of Ewes in Early Pregnancy. Vet Pathol 38: 275-280 [Abstract] [Full Text]