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Infect Immun. 1977 February; 15(2): 576-585

Interactions between calf alveolar macrophages and parainfluenza-3 virus.

M Probert, E J Stott and L H Thomas

ABSTRACT

Cells washed from the lungs of freshly killed calves (lung wash cells; LWC) were cytotoxic for calf kidney (CK) target cells infected with parainfluenzavirus type 3 (Pi-3) when assayed by chromium release. LWC collected from 25 calves, including two gnotobiotic animals that had not previously been infected with Pi-3, were all cytotoxic, giving a specific chromium release between 11 and 50%. Cytotoxicity was detected at ratios of LWC to target cell as low as 5:1. The cytotoxic reaction required viable LWC, was inhibited by Pi-3 antiserum, and was not the result of virus-induced damage to the target cells. The cytotoxic cells in the LWC population were identified as alveolar macrophages from observations on glass adherence, phagocytic activity, killing by silica and fine-structural appearance. When LWC were added to CK cells or organ cultures of bovine trachea infected with Pi-3, the yield of virus was reduced for the first 2 to 3 days. However, subsequently, Pi-3 virus replicated in the LWC. Infection of LWC with Pi-3 virus reduced their cytotoxic activity. The significance of these interactions between alveolar macrophages and Pi-3 virus is discussed.

Infect Immun. 1977 February; 15(2): 576-585




This article has been cited by other articles:

  • Li, X., Castleman, W. L. (1991). Effects of 4-Ipomeanol on Bovine Parainfluenza Type 3 Virus-induced Pneumonia in Calves. Veterinary Pathology 28: 428-437 [Abstract]  


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