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Infect Immun. 1977 March; 15(3): 772-775

Reliable in vivo model for latent herpes simplex virus reactivation with peripheral virus shedding.

A B Nesburn, M T Green, M Radnoti and B Walker

ABSTRACT

A long-sought laboratory model, a reliable system for in vivo reactivization of latent herpes simplex infection with peripheral shedding of active virus, is present. Results demonstrate that surgical stimulation of latently infected rabbit trigeminal ganglia induces peripheral release of infectious herpes simplex virus. Virus could be cultured from the tear film in 83% of the stimulated animals' eyes within 48 h.

Infect Immun. 1977 March; 15(3): 772-775






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Copyright © 1977 by the American Society for Microbiology. All rights reserved.