This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Stiver, H G Articles by Eickhoff, T C Search for Related Content PubMed PubMed Citation Articles by Stiver, H G Articles by Eickhoff, T C

 Previous Article  |  Next Article 

Infect Immun. 1977 June; 16(3): 738-741

Impaired serum antibody response to inactivated influenza A and B vaccine in renal transplant recipients.

ABSTRACT

Before and after vaccination with a commercial inactivated influenza vaccine containing A/Aichi/2/68 (H3N2) and B/Massachusetts/1/71 antigens, the serum hemagglutination inhibition antibody titers to homologous and heterologous strains of A and B influenza viruses were measured in 45 renal transplant patients and 66 healthy controls (62 for the B strains). At least a fourfold titer rise to the homologous A strain occurred in 14 of 45 transplant patients (31%) versus 37 of 66 controls (56%). Fourfold or greater heterologous A rises occurred in only 8 of 45 transplant patients (18%) compared with 40 of 60 controls (61%). In both the homologous and heterologous B responses, at least fourfold hemagglutination inhibition titer rises were seen in significantly fewer transplant patients than control subjects. In the transplant group, no correlation was observed between degree of antibody response and age, previous influenza vaccination, percentage of patients initially seronegative, time since transplantation, dose of immunosuppressive drugs, level of renal function, or nature of original renal disease.

This article has been cited by other articles:

• Duchini, A., Goss, J. A., Karpen, S., Pockros, P. J. (2003). Vaccinations for Adult Solid-Organ Transplant Recipients: Current Recommendations and Protocols. Clin. Microbiol. Rev. 16: 357-364 [Abstract] [Full Text]  
• Mazzone, P.J., Mossad, S.B., Mawhorter, S.D., Mehta, A.C., Schilz, R.J., Maurer, J.R. (2001). The humoral immune response to influenza vaccination in lung transplant patients. Eur Respir J 18: 971-976 [Abstract] [Full Text]  
• KASISKE, B. L., VAZQUEZ, M. A., HARMON, W. E., BROWN, R. S., DANOVITCH, G. M., GASTON, R. S., ROTH, D., SCANDLING, J. D. JR., SINGER, G. G. (2000). Recommendations for the Outpatient Surveillance of Renal Transplant Recipients. J. Am. Soc. Nephrol. 11: S1-S86 [Abstract] [Full Text]  
• Pirofski, L.-a., Casadevall, A. (1998). Use of Licensed Vaccines for Active Immunization of the Immunocompromised Host. Clin. Microbiol. Rev. 11: 1-26 [Abstract] [Full Text]