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Infect Immun. 1977 June; 16(3): 821-826

Prevention of recrudescent malaria in nude mice by thymic grafting or by treatment with hyperimmune serum.

D W Roberts, R G Rank, W P Weidanz and J F Finerty

ABSTRACT

Nude mice died when infected with the normally avirulent malarial parasite Plasmodium berghei yoelii. Furthermore, malaria recrudesced in Nu/Nu mice after the termination of acute disease by treatment with clindamycin. Recrudescence was not observed in Nu/Nu mice that had been grafted with thymic tissue or treated with hyperimmune serum. Mice mad B cell deficient by treatment with anti-mu-chain serum also died when infected with P. berghei yoelii. The data suggest that a crucial role of the thymus in preventing recrudescent malaria in this model system is to provide a helper function in the production of protective antibody.

Infect Immun. 1977 June; 16(3): 821-826






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