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Infect Immun. 1977 June; 16(3): 849-852

Effect of anti-mu-chain-specific immunosuppression on Chikungunya virus encephalitis of mice.

M Giovarelli, I Viano, M Zucca, R Valbonesi and F Dianzani

ABSTRACT

Mice neonatally immunosuppressed with anti-mu antiserum failed to produce circulating antibodies to sheep erythrocytes and showed a marked decrease in circulating immunoglobulins. However, when they were intracerebrally infected with Chikungunya virus (a group A togavirus), they showed a mortality rate consistently lower than non-immunosuppressed control mice. Several possible explanations for this finding are discussed.

Infect Immun. 1977 June; 16(3): 849-852






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