This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Clark, R A
Right arrow Articles by Wilde, G
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Clark, R A
Right arrow Articles by Wilde, G

 Previous Article  |  Next Article 

Infect Immun. 1977 December; 18(3): 694-700

Defective neutrophil chemotaxis in juvenile periodontitis.

R A Clark, R C Page and G Wilde

ABSTRACT

Neutrophil chemotaxis was evaluated in nine patients with juvenile periodontitis, with normal subjects and patients with the adult form of periodontitis as controls. Defective chemotactic responses were observed in neutrophils from seven of nine juvenile patients, and a reduced level of complement-derived chemotactic activity was demonstrated in serum from four patients. These determinations were normal in all the patients with adult periodontitis. Serum from five of the juvenile patients contained a heat-stable, non-dialyzable factor that markedly inhibited the chemotaxis of normal neutrophils. Thus the characteristic tissue destruction seen in juvenile periodontitis may be, at least in part, a consequence of a failure of host defense mechanisms.

Infect Immun. 1977 December; 18(3): 694-700




This article has been cited by other articles:

  • Ye, R. D., Boulay, F., Wang, J. M., Dahlgren, C., Gerard, C., Parmentier, M., Serhan, C. N., Murphy, P. M. (2009). International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the Formyl Peptide Receptor (FPR) Family. Pharmacol. Rev. 61: 119-161 [Abstract] [Full Text]  
  • Page, R.C. (1995). Critical Issues in Periodontal Research. JDR 74: 1118-1128 [Abstract]  
  • Groves, D.T., Jiang, Y. (1995). Chemokines, a Family of Chemotactic Cytokines. CROBM 6: 109-118 [Abstract] [Full Text]  
  • Ranney, R.R. (1991). Diagnosis of Periodontal Diseases. ADR 5: 21-36 [Abstract]  
  • Ishikawa, I., Watanabe, H., Horibe, M., Izumi, Y. (1988). Diversity of IgG Antibody Responses in the Patients with Various Types of Periodontitis. ADR 2: 334-338 [Abstract]  
  • Van Dyke, T.E., Offenbacher, S., Kalmar, J., Arnold, R.R. (1988). Neutrophil Defects and Host-Parasite Interactions in the Pathogenesis of Localized Juvenile Periodontitis. ADR 2: 354-358 [Abstract]  
  • Pelkonen, P., Ryoppy, S., Jaaskelainen, J., Rapola, J., Repo, H., Kaitila, I. (1988). Chronic Osteomyelitislike Disease With Negative Bacterial Cultures. Arch Pediatr Adolesc Med 142: 1167-1173 [Abstract]  
  • Kulasekara, B. (1988). Juvenile Periodontitis (Periodontosis) in a Nigerian Teaching Hospital. The Journal of the Royal Society for the Promotion of Health 108: 110-112 [Abstract]  
  • Genco, R.J., Van Dyke, T.E., Levine, M.J., Nelson, R.D., Wilson, M.E. (1986). 1985 Kreshover lecture. Molecular Factors Influencing Neutrophil Defects in Periodontal Disease. JDR 65: 1379-1391 [Abstract]  
  • Cogen, R.B., Roseman, J.M., Al-Joburi, W., Louv, W.C., Acton, R.T., Barger, B.O., Go, R.C.P., Rasmussen, R.A. (1986). Host Factors in Juvenile Periodontitis. JDR 65: 394-399 [Abstract]  
  • Genco, R.J., Slots, J. (1984). Host Responses Host Responses in Periodontal Diseases. JDR 63: 441-451  
  • Van Dyke, T.E. (1984). Neutrophil Receptor Modulation in the Pathogenesis of Periodontal Diseases. JDR 63: 452-454 [Abstract]  
  • Van Dyke, T.E., Levine, M.J., Tabak, L.A., Genco, R.J. (1983). Juvenile Periodontitis as a Model for Neutrophil Function: Reduced Binding of the Complement Chemotactic Fragment, C5a. JDR 62: 870-872 [Abstract]  
  • Nagumo, M., Sakurada, S., Enomoto, S. (1982). Clinical Science: Membrane Receptors on Human Neutrophils in Oral Bacterial Infections. JDR 61: 962-966 [Abstract]  
  • Barnett, M.L., Baker, R.L., Yancey, J.M. (1982). The Prevalence of Juvenile Periodontitis ("Periodontosis") in a Dental School Patient Population. JDR 61: 391-392 [Abstract]  
  • GALLIN, J. I., WRIGHT, D. G., MALECH, H. L., DAVIS, J. M., KLEMPNER, M. S., KIRKPATRICK, C. H. (1980). Disorders of Phagocyte Chemotaxis. ANN INTERN MED 92: 520-538 [Abstract]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»