This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Stebbing, N Articles by Lindley, I J Search for Related Content PubMed PubMed Citation Articles by Stebbing, N Articles by Lindley, I J

 Previous Article  |  Next Article 

Infect Immun. 1978 January; 19(1): 5-11

Requirement for macrophages for interferon to be effective against encephalomyocarditis virus infection of mice.

ABSTRACT

Suppression of macrophages in mice by treatments with silica or auro-thiomalate (Myocrisin) reduced production of serum interferon by polyriboinosinic acid:polyribocytidylic acid by 85 to 90%, indicating that this double-stranded polynucleotide caused interferon production primarily in macrophages. Suppression of macrophages in mice by silica or Myocrisin treatment did not significantly affect the susceptibility of mice to encephalomyocarditis virus, although at virus doses around 20 times the 50% lethal dose they died about 48 h earlier. Macrophage interferon protected mice from encephalomyocarditis virus infection at much lower doses than fibroblast interferon, and treatment of mice with silica or Myocrisin abolished the protection conferred by macrophage interferon, whereas these treatments had a much smaller effect on the protection afforded by fibroblast interferon. The requirement for macrophages for interferon to be effective in mice can explain why macrophage suppression can cause normally nonlethal viruses to kill adult mice.

This article has been cited by other articles:

• Smith, A. D., Guidry, C. A., Morris, V. C., Levander, O. A. (1999). Aurothioglucose Inhibits Murine Thioredoxin Reductase Activity In Vivo. J. Nutr. 129: 194-198 [Abstract] [Full Text]