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Infect Immun. 1970 July; 2(1): 11-14
Copyright © 1970 American Society for Microbiology. All Rights Reserved.

Decreased Growth Capacity of Passaged Gross Virus-Induced Mouse Lymphomas After Incubation with Antithymocytic Sera

Laboratory of Nuclear Medicine and Radiation Biology, School of Nursing, University of California, Los Angeles, California 90024
² Department of Medicine, School of Medicine, Center for the Health Sciences, University of California, Los Angeles, California 90024

ABSTRACT

AKR or C3H/HeJ transplanted mouse lymphomas, originally induced by Gross virus, could be neutralized by in vitro incubation with an immunosuppressive rabbit anti-mouse thymus cell serum. Neutralization was measured by significantly increased latent periods or decreased incidence (at a minimum of 90 days post-transfer) of lymphoma in syngeneic recipients of lymphoma cells incubated with antithymocytic serum when compared with syngeneic recipients of lymphoma cells incubated with normal rabbit serum.