This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Shayegani, M. Search for Related Content PubMed PubMed Citation Articles by Shayegani, M.

 Previous Article  |  Next Article 

Infect Immun. 1970 December; 2(6): 742-749
Copyright © 1970 American Society for Microbiology. All Rights Reserved.

Failure of Immune Sera to Enhance Significantly Phagocytosis of Staphylococus aureus: Nonspecific Adsorption of Phagocytosis-Promoting Factors

Department of Community Medicine, School of Medicine, University of Pennsylvania
Department of Clinical Pathology, Philadelphia General Hospital
U.S. Veterans Administration Hospital, Philadelphia, Pennsylvania 19104

ABSTRACT

Serum from rabbits immunized with either heat-killed or live nonencapsulated Staphylococcus aureus failed further to enhance phagocytosis and intracellular killing of the homologous organism by either normal rabbit polymorphonuclear leukocytes or monocytes, when compared with normal rabbit serum. These immune sera did, however, show an increase in agglutinating and precipitating antibody level. Adsorption of normal human serum with some gram-positive and gram-negative bacteria, yeast, and some inert particles significantly reduced the phagocytosis-promoting factors of the serum. It would seem, then, that nonencapsulated S. aureus differs from other pathogenic bacteria in that the humoral antibacterial factors promoting its phagocytosis and intracellular killing are not significantly enhanced by infection or immunization.

This article has been cited by other articles:

• Ohwada, A., Sekiya, M., Hanaki, H., Arai, K. K., Nagaoka, I., Hori, S., Tominaga, S., Hiramatsu, K., Fukuchi, Y. (1999). DNA vaccination by mecA sequence evokes an antibacterial immune response against methicillin-resistant Staphylococcus aureus. J Antimicrob Chemother 44: 767-774 [Abstract] [Full Text]