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Infect Immun. 1970 December; 2(6): 810-814
Copyright © 1972 American Society for Microbiology. All Rights Reserved.

Effect of Antimacrophage Serum on Dermal Tuberculin Sensitivity and Allergic Pulmonary Granuloma Formation in Rabbits

¹ Department of Microbiology, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, North Carolina 27103

ABSTRACT

Anti-rabbit alveolar macrophage goat serum (AMS), adsorbed of hemolysins and hemagglutinins, exhibited complement-dependent cytotoxicity for the following rabbit target cells: alveolar macrophages, thymocytes, and kidney (RK-13) cells. The intravenous injection of AMS, sufficient to reduce markedly the dermal tuberculin reaction in BCG-sensitized rabbits, did not suppress the development of BCG-induced chronic and accelerated pulmonary granulomas. These observations are discussed in relation to delayed sensitivity, allergic granuloma formation, and cell-associated immunity.