This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via Google Scholar Google Scholar Articles by White-Scharf, M E Articles by Rosenberg, L T Search for Related Content PubMed PubMed Citation Articles by White-Scharf, M E Articles by Rosenberg, L T

 Previous Article  |  Next Article 

Infect Immun. 1978 October; 22(1): 18-21

Evidence that L-rhamnose is the antigenic determinant of hyporesponsiveness of BALB/c mice to Klebsiella pneumoniae type 47.

ABSTRACT

The genetic polymorphism in early, immunoglobulin M, responsiveness to the Klebsiella pneumoniae type 47 polysaccharide (K47-PS) is determinant specific, and L-rhamnose is probably the determinant against which differential responsiveness is expressed. This is inferred from tests of the response to the cross-reacting Streptococcus pneumoniae type 23 and non-cross-reacting pneumococcal polysaccharides of known chemical construction. B10.2/Sn new-line mice are high responders and BALB/c mice are low responders to K47-PS. Upon immunization with killed S. pneumoniae type 23, these strains produce cross-reacting antibody to K47-PS. The cross-reacting antibody responses of these strains are congruent with their responses to K47-PS.