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Infect Immun. 1978 December; 22(3): 644-648

Comparative studies of five heat-labile toxic products of Escherichia coli.

J Konowalchuk, N Dickie, S Stavric and J I Speirs

ABSTRACT

Five heat-labile, partially purified toxic products of Escherichia coli were distinguished by isoelectric focusing, molecular weight, and neutralization with homologous and heterologous antisera. Only two affected the morphology of Y-1 cells, induced fluid accumulation in rabbit ileal loops, and stimulated production of cyclic AMP in Vero cells; these two did not cross-neutralize and only one showed cross-neutralization with cholera antitoxin. The remaining three products were cytotoxic for Vero cells.

Infect Immun. 1978 December; 22(3): 644-648




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