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Infect Immun. 1979 March; 23(3): 706-710

Mitogenic activity of staphylococcal peptidoglycan.

R Dziarski and A Dziarski

ABSTRACT

Staphylococcus aureus peptidoglycan displayed a marked dose-dependent mitogenic activity for mouse splenocytes and human peripheral blood lymphocytes in vitro, as measured by increased [3H]thymidine incorporation. Similarly it was mitogenic for athymic nude mouse spleen cells, whereas no blastogenic effect was observed in T cell-enriched and B cell-depleted mouse lymphocyte cultures. These data demonstrate that peptidoglycan-responding cells in mouse spleen cell cultures are B lymphocytes.

Infect Immun. 1979 March; 23(3): 706-710




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