This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Roumillat, L F Articles by Lukert, P D Search for Related Content PubMed PubMed Citation Articles by Roumillat, L F Articles by Lukert, P D

 Previous Article  |  Next Article 

Infect Immun. 1979 May; 24(2): 539-544

Persistent infection of a human lymphoblastoid cell line with equine herpesvirus 1.

ABSTRACT

Infection of a human lymphoblastoid cell line (Jijoye line derived from a Burkitt lymphoma which contains Epstein-Barr virus) with equine herpesvirus 1, maintained and observed for 53 days, was characterized by the continuous production of infectious extracellular and intracellular virus. Maximum virus production correlated with active cell multiplication. Less than 15% of the cells possessed viral capsid antigen at any one time. Five percent of the cells in the Jijoye line possess Epstein-Barr viral capsid antigen; 80% of the Epstein-Barr viral caspid-containing cells also contained equine herpesvirus 1 antigen as detected by double staining. The interaction of equine herpesvirus 1 and lymphoblastoid cells provides a useful in vitro model which may help clarify the mechanism for herpesvirus latency.