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Human neutrophil migratory function: modulatory effect of interactions with opsonized particles.

ABSTRACT

Human polymorphonuclear neutrophils preexposed to cytotaxin or to phagocytizable particles exhibited reduced spontaneous and chemotactic migratory responses. This influence of cytotaxin appears to be related to toxic effects of by-products of hexose monophosphate shunt stimulation. To determine whether a phagocytic stimulus may inhibit subsequent neutrophil migratory functions by the same mechanism, we assessed spontaneous and chemotactic migratory functions of neutrophils from individuals with chronic granulomatous disease exposed to antibody-opsonized sheep erythrocytes. Our results showed that phagocytosis of such particles did not alter these migratory responses of chronic granulomatous disease neutrophils and suggest that phagocytic stimulation of normal neutrophils may modulate migratory function by some mechanism dependent upon hexose monophosphate shunt stimulation.