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Infect Immun. 1980 August; 29(2): 335-341

Influence of complement on the chemiluminescent response of human leukocytes to immune complex.

S Löfgren, A Tärnvik and J Carlsson

ABSTRACT

Vaccine bacteria of Francisella tularensis were mixed with human serum containing specific antibodies against the same organism, and the mixture was incubated at 37 degrees C for 30 min. The mixture induced a two-peak chemiluminescent response in polymorphonuclear leukocytes. The initial peak was induced by a soluble agent, formed during incubation. The formation of this agent involved the activation of complement component C5. The second peak of the chemiluminescent response was induced by the opsonized bacteria; this peak was augmented by complement component C3, whereas C5 had no influence.

Infect Immun. 1980 August; 29(2): 335-341






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