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Infect Immun. 1971 January; 3(1): 10-15
Copyright © 1971 American Society for Microbiology. All Rights Reserved.

Occurrence of Protein A in Staphylococcal Strains: Quantitative Aspects and Correlation to Antigenic and Bacteriophage Types

Department of Medicine, University of New Mexico, Albuquerque, New Mexico 87106
Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455

ABSTRACT

Protein A of Staphylococcus aureus can be detected on cell walls of intact bacteria by use of radioactively labeled myeloma globulin. Of 156 strains of S. aureus, 141 (90%) contained protein A. None of 47 S. epidermidis strains was positive for protein A. The production of protein A was influenced by incubation temperature but not by differences in incubation time or inoculum size. A medium containing a high concentration of NaCl suppressed the production of protein A by 90%. Formalin treatment of protein A-containing strains caused a decrease in the amount detected, but no further decrease was detected after storage at 4 C. No correlation was found between absence or presence of protein A and phage type or phage group. Sixteen S. aureus strains were studied extensively. There was no correlation between protein A and any of the 26 antigenic characteristics which have been previously described in these strains.

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