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Infect Immun. 1971 January; 3(1): 159-163
Copyright © 1971 American Society for Microbiology. All Rights Reserved.

Post-Transfusion Cytomegaloviremia and Persistence of Cytomegalovirus in Blood ¹

^a Division of Immunology, Sloan-Kettering Institute and Infectious Disease Service, Department of Medicine, Memorial Hospital, New York, New York 10021

ABSTRACT

Cytomegaloviremia was documented in seven patients. Three patients were renal transplant recipients and two were liver transplant recipients. One was a postcardiac surgery patient, and one had acute myelogenous leukemia. The transplant patients had received only banked blood or fresh frozen plasma and developed evidence of infection about 1 month after surgery. Illness varied from no apparent signs to fever alone, fever and a morbilliform rash, hepatitis and an infectious mononucleosis syndrome. The virus was isolated from the blood erythrocyte layer, the leukocyte layer, and the plasma and serum, in that order of frequency. In vitro studies demonstrated persistence of inoculated cytomegalovirus in the presence of erythrocytes (and tissue culture media) for up to 21 days. In whole blood under banking conditions, inoculated virus was recovered after 28 days and, in fresh frozen plasma, after 97 days.

¹ Requests for reprints should be addressed to: Dr. D. Armstrong, 444 East 68th Street, New York, N.Y. 10021.

This article has been cited by other articles:

• Schrier, R., Nelson, J., Oldstone, M. (1985). Detection of human cytomegalovirus in peripheral blood lymphocytes in a natural infection. Science 230: 1048-1051 [Abstract]