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Infect Immun. 1971 January; 3(1): 167-170
Copyright © 1971 American Society for Microbiology. All Rights Reserved.

Clostridium perfringens Type A Food Poisoning I. Response of the Rabbit Ileum as an Indication of Enteropathogenicity of Strains of Clostridium perfringens in Monkeys

Food Research Institute and Departments of Bacteriology and Food Science, University of Wisconsin, Madison, Wisconsin 53706

ABSTRACT

Diarrhea and vomiting have been experimentally produced in monkeys after oral challenge with viable cells or culture filtrates of certain strains of Clostridium perfringens that previously had been shown to produce either fluid accumulation in the ligated ileum or overt diarrhea in the nonligated ileum of the rabbit, or both. Strains (or their culture filtrates) which did not produce a response in the rabbit likewise produced no symptoms in monkeys.