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Acid Phosphatase Cytochemistry of Phagocytizing Leukocytes from Patients with Chronic Granulomatous Disease

¹ Department of Medicine, Mount Sinai School of Medicine, of The City University of New York, New York, New York 10029
² Department of Pathology, Medical University of South Carolina, Charleston, South Carolina 29401

ABSTRACT

Studies of neutrophils and eosinophils from normal individuals, patients with chronic granulomatous disease of childhood, and their heterozygous mothers demonstrate degranulation and vacuolization during phagocytosis of opsonized Escherichia coli. Acid phosphatase reactivity is demonstrated in some primary granules of neutrophils and around crystalloids of some eosinophil granules and is comparable for cells from the three groups of individuals studied. Strong acid phosphatase reactivity is consistently demonstrated in phagocytic vacuoles of both cell types in cells from normal and affected individuals.