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Infect Immun. 1971 January; 3(1): 73-79
Copyright © 1971 American Society for Microbiology. All Rights Reserved.

A Chromosomal Locus Which Controls the Ability of Shigella flexneri to Evoke Keratoconjunctivitis

Samuel B. Formal, P. Gemski Jr., L. S. Baron and E. H. LaBrec

1 Department of Applied Immunology and Department of Bacterial Immunology, Walter Reed Army Institute of Research, Washington, D.C. 20012

ABSTRACT

The primary step in the pathogenesis of bacillary dysentery is the penetration of intestinal epithelial cells by shigellae. Lacking this capacity, Shigella flexneri becomes avirulent. By means of intergeneric conjugation between various Escherichia coli K-12 Hfr strains and S. flexneri 2a virulent recipients and by reciprocal transduction analysis with phage P1 vir, we established a locus on the genome of S. flexneri 2a which is necessary for the ability of this strain to penetrate epithelial cells as measured by the Sereney test for keratoconjunctivitis. This locus, termed kcpA (in reference to its involvement in provoking keratoconjunctivitis), has been positioned between the lac and gal chromosomal markers and is contransducible with the purE allele.

Infect Immun. 1971 January; 3(1): 73-79
Copyright © 1971 American Society for Microbiology. All Rights Reserved.



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