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Infect Immun. 1971 February; 3(2): 249-253
Copyright © 1971 American Society for Microbiology. All Rights Reserved.

Mouse Resistance Against Foot-and-Mouth Disease Virus Induced by Injections of Pyran

^a Plum Island Animal Disease Laboratory, Veterinary Sciences Research Division, Agricultural Research Service, U.S. Department of Agriculture, Greenport, New York 11944

ABSTRACT

Mouse resistance to foot-and-mouth disease virus (FMDV) was induced by intraperitoneal injections of pyran copolymer. A biphasic pattern of protection occurred with greatest resistance 4 and 48 hr after injection of this polyanion. Viremia was not detectable in pretreated mice challenge-exposed with FMDV. Incubation of virus with pyran did not alter viral infectivity in mice or tissue culture. Serum interferon was demonstrated 1 and 2 days after pyran administration.

¹ Part of this work was done while in pursuance of a Postdoctoral Resident Research Associateship of the Agricultural Research Service and the National Academy of Sciences, National Research Council.