This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Krahenbuhl, J. L. Articles by Lysenko, M. G. Search for Related Content PubMed PubMed Citation Articles by Krahenbuhl, J. L. Articles by Lysenko, M. G.

 Previous Article  |  Next Article 

Infect Immun. 1971 February; 3(2): 260-267
Copyright © 1971 American Society for Microbiology. All Rights Reserved.

In Vivo and In Vitro Studies of Delayed-Type Hypersensitivity to Toxoplasma gondii in Guinea Pigs

^a Department of Medical Microbiology, University of Wisconsin Medical School, Madison, Wisconsin 53706

ABSTRACT

Delayed-type hypersensitivity develops late in the course of human toxoplasmosis, and a positive skin test is of some value for implicating chronic or eliminating acute forms of toxoplasmosis as a cause of disease. Toxoplasma-infected guinea pigs were studied to determine the onset and development of delayed-type hypersensitivity. Both the toxoplasmin skin test and the in vitro macrophage migration inhibition technique indicated that delayed hypersensitivity to toxoplasma antigen existed as early as 1 week after infection. The mechanism responsible for the observed inhibition of macrophage migration in vitro appeared to be an inhibitory factor(s) released from sensitized lymphoid cells in the presence of antigen.

¹ Present address: Palo Alto Medical Research Foundation, Palo Alto, Calif. 94301.