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Infect Immun. 1971 February; 3(2): 304-307
Copyright © 1971 American Society for Microbiology. All Rights Reserved.

Effect of Antilymphocyte Serum on Reovirus Infection of Mice

Department of Microbiology, Tohoku University School of Dentistry, Sendai 980, Japan

ABSTRACT

Reovirus type 3 infection in mice was investigated, with particular reference to the effect of antilymphocyte serum. With virus inoculation, a characteristic acute disease was manifested in the mice younger than 5 days old but not in mice 7 days old or older. However, a single injection of antilymphocyte serum, which was prepared in rabbits immunized with mouse thymocytes, followed by virus inoculation induced the acute disease in mice 7 days old or older. The latter result suggests that this production of the acute disease may be due to a suppression of the cellular immune mechanism sensitive to antilymphocyte serum.