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Antibody Formation in Rabbits Adapted and Nonadapted to High Altitude

Microbiology and Pathology Divisions, U.S. Army Medical Research and Nutrition Laboratory, Fitzsimons General Hospital, Denver, Colorado 80240

ABSTRACT

Antibody formation in high-altitude-acclimatized and nonacclimatized rabbits was investigated at altitudes of 14,100 (Pikes Peak, Colo.) and 5,330 (Denver, Colo.). Serum pools representing samplings of primary response were titered before and after treatment with 2-mercaptoethanol. Peak titers of 2-mercaptoethanolresistant and -sensitive humoral antibodies were higher in the animals adapted to an altitude of 14,100 ft and in nonadapted animals than in animals maintained at 5,330 ft.