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Infect Immun. 1971 March; 3(3): 385-389
Copyright © 1971 American Society for Microbiology. All Rights Reserved.

Group A Streptococcal Polysaccharide Antigens

Takashi Matsuno and Hutton D. Slade

1 Department of Microbiology, Northwestern University Medical School, Chicago, Illinois 60611

ABSTRACT

Cold trichloroacetic acid extracts of group A, type 3 streptococci were fractionated on Sephadex G50 and ECTEOLA cellulose columns. A glucose-N-acetylglucosamine polymer was isolated and shown by chemical, electrophoretic, and antigenic analysis to be distinct from the group A polysaccharide. The antigenic specificity was due to the glucosamine. A glycerol-phosphate-alanine-glucosamine teichoic acid polymer was isolated. The antigenic specificity was due to N-acetylglucosamine and D-alanine methyl ester, with the former possessing principal responsibility. The glucosamine and ester-linked alanine appear to be labile to the method of extraction and fractionation. Group A streptococcal whole cell antiserum, after adsorption with cells of a heterologous serological group and group A polysaccharide antigen, contained antibodies against both polymers.

Infect Immun. 1971 March; 3(3): 385-389
Copyright © 1971 American Society for Microbiology. All Rights Reserved.



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