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Delayed Hypersensitivity Induced in Guinea Pigs by 7, 12-Dimethylbenz(a) anthracene

Surgical Research Laboratory, Veterans Administration Hospital, Portland, Oregon 97207
Department of Surgery, University of Oregon Medical School, Portland, Oregon 97201
Department of Bacteriology and Public Health, Washington State University, Pullman, Washington 99164

ABSTRACT

A delayed hypersensitivity to 7, 12-dimethylbenz(a)anthracene was elicited in guinea pigs after contact sensitization. This sensitivity was characterized by its time of appearance, histology, specificity, and transfer characteristics. The reaction had its maximal dermal reactivity 24 hr after challenge, was characterized by a mononuclear cell infiltration, demonstrated immunological specificity, and could be transferred with leukocytes to normal animals.