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Role of Complement During Experimental Candida Infection in Mice

Department of Medical Microbiology, Stanford University, Stanford, California 94305

ABSTRACT

The role of complement during experimental Candida albicans infection was investigated in mice. It was found that complement-positive CF-1 mice, infected with the test organism, survived significantly longer than complement-deficient mice of the same strain. This implies the participation of the relatively late acting complement component in host defense mechanisms directed against this systemic mycotic infection.

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