This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Allen, S. L. Articles by Peterson, D. Search for Related Content PubMed PubMed Citation Articles by Allen, S. L. Articles by Peterson, D.

Metabolism of Common Substrates by the Reiter Strain of Treponema pallidum

Department of Microbiology, University of Minnesota, Minneapolis, Minnesota 55455

ABSTRACT

The utilization of glucose, amino acids, fatty acids, bicarbonate, purines, and pyrimidines by the Reiter treponeme was studied by using carbon 14-labeled substrates. The distribution of carbon from the substrates into various cell components was determined. Radioactivity from labeled bicarbonate in the cellular protein was restricted to aspartic acid. The Reiter treponeme is capable of synthesizing glycine, serine, alanine, aspartic acid, glutamic acid, proline, and possibly ornithine. Phenylalanine, arginine, lysine, leucine, isoleucine, valine, threonine, and histidine do not appear to be synthesized by this treponeme. The Reiter treponeme cannot synthesize fatty acids, and thymine is not incorporated. Glucose is a major carbon and energy source. Arginine, histidine, serine, threonine, and glutamic acid are degraded by the Reiter treponeme and may serve as energy sources. It was calculated that exogenously supplied amino acids contribute 41 to 54% of the cellular material; fatty acids, 18%; and glucose, 28 to 43%.