This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via Google Scholar Google Scholar Articles by McCormick, K. J. Articles by Trentin, J. J. Search for Related Content PubMed PubMed Citation Articles by McCormick, K. J. Articles by Trentin, J. J.

Complement-Fixing Antigens in Burkitt Lymphoma Cell Lines

Division of Experimental Biology, Baylor College of Medicine, Houston, Texas 77025
Department of Pediatrics, University of Texas M. D. Anderson Hospital and Tumor Institute, Houston, Texas 77025

ABSTRACT

The complement-fixing (CF) activity of antigens from cultured Burkitt lymphoma cells was determined by using normal American sera as the source of antibody. Approximately 75% of the sera fixed complement with the positive cell lines. These lines contained the herpes-like virus detectable by electron microscopy. The content of CF antigen depended on the cell line used but appeared to be independent of the number of cells which produced Henle's immunofluorescence (IF) antigen. Only sera that reacted in the IF test also contained CF antibodies to the crude cell extracts.