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Cytochemical and Immunofluorescence Study of an Oncogenic Avian Adenovirus (CELO) in Mammalian Cell Cultures

¹ Animal Pathology Department, University of Rhode Island, Kingston, Rhode Island 02881

ABSTRACT

Chicken embryo lethal orphan (CELO) virus replication studies in adult hamster kidney and green monkey kidney cell cultures by means of infectivity, cytochemistry, and fluorescent-antibody techniques indicated that replication in hamster kidney cells was limited to the production of neoantigen. Production of virus in green monkey kidney cells was limited but appeared to exceed the production of virus in hamster kidney cells. The data indicated that the replication cycle of CELO virus is abortive in hamster kidney and green monkey kidney cells.