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Infect Immun. 1971 September; 4(3): 269-273
Copyright © 1971 American Society for Microbiology. All Rights Reserved.

Renal Lysozyme Levels in Animals Developing "Sterile Pyelonephritis"

¹ Research and Development Department, The Norwich Pharmacol Company, Norwich, New York 13815

ABSTRACT

The induction of sterile unilateral pyelonephritis in rats with heat-killed Proteus mirabilis cells is described. The lesions were identical to those produced with viable bacteria. Lysozyme levels in both kidneys of rats developing unilateral sterile pyelonephritis underwent biphasic elevations similar to those produced with viable bacteria. In the injected kidney, the first elevation, associated with the trauma of injection, could be produced by injecting sterile saline. The second elevation was associated with the onset of chronicity in the injected kidney. The nonmanipulated, contralateral kidney showed a similar biphasic elevation, of equal duration but of greater magnitude.